Chromatin Topological Transitions

Chromatin topological transitions

Distinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation

The human genome is segmented into Topologically Associating Domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we described the distribution of Progestin-induced chromatin modifications and changes in transcriptional activity over TADs in T47D breast cancer cells. Using ChIP-Seq, Hi-C and 3D modelling techniques, we found ...

Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation.

The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the distribution of progestin-induced chromatin modifications and changes in transcriptional activity over TADs in T47D breast cancer cells. Using ChIP-seq (chromatin immunoprecipitation combined with ...

Topological Aspects of Phase Transitions

In the past decade and a half, an alternative analysis of phase transitions, based in the topological behavior of system configuration spaces, has been introduced. This method offers a new understanding of many phase transitions, particularly those in finite systems, using topology and manifold behavior. While the broadest hypotheses offered by researchers have proven overly optimistic, the met...

Multifarious topological quantum phase transitions in two-dimensional topological superconductors

We study the two-dimensional topological superconductors of spinless fermions in a checkerboard-lattice Chern-insulator model. With the short-range p-wave superconducting pairing, multifarious topological quantum phase transitions have been found and several phases with high Chern numbers have been observed. We have established a rich phase diagram for these topological superconducting states. ...